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The best biotech opportunities disrupt large and established markets with new technologies capable of improving efficacy and/or lowering cost. For example, Intuitive Surgical Inc.’s (ISRG) built a multi-billion-dollar business by making surgical robots – known as Da Vinci Systems – capable of executing a greater number of procedures with a high level of precision, while making surgeries much less invasive in nature for patients.
Cardiovascular disease is responsible for one-in-four deaths each year in the United States, or roughly 610,000 deaths each year, making it the leading cause of death in both men and women, according to the Centers for Disease Control. Despite causing more deaths than cancer each year, many cardiovascular drugs are based on loose associations rather than the precision genetic targeting that underlies many oncology drugs.
Diabetes is a large and growing problem in the U.S. and around the world. In the U.S., there are an estimated 21 million diagnosed cases, and an additional eight million undiagnosed cases, of diabetes, according to the Centers for Disease Control. The International Diabetes Foundation currently projects approximately 387 million people worldwide are suffering from the disease, with that figure expected to jump to nearly 600 million by 2035 – just 20 years from now.
Diabetes affects approximately 387 million people worldwide and that figure is expected to soar to nearly 600 million by 2035, according to the International Diabetes Federation. At the same time, global health expenditures tied to diabetes are expected to surge to nearly a half billion dollars over the coming years, as the world’s population ages and puts an increasingly large burden on healthcare systems to cover the costs of treatment.
For much of 2015, the Bitcoin market has been at something of a standstill. Following a burst to a lucrative value exceeding $950 in late 2013, the digital currency plummeted back to Earth at a fairly steady pace through most of last year. These trends were easy enough to explain: in very general terms, Bitcoin was snatched up quickly when its very creation seemed to promise the birth of what ultimately became a dominant new currency. Then, when financial analysts either condemned Bitcoin or stressed that it needed time to develop, public enthusiasm waned, leading to the decline in value.
Reinsurance is one of the few hedge fund strategies that has almost no correlation to the stock or bond markets and has the potential to generate high single digit to low double digit returns on average over the next 5 to 10 years, regardless of the direction of the capital markets. It is important for investors to stress test their overall portfolio for major market selloffs, because most hedge fund strategies’ correlations to the capital markets are dynamic and rise dramatically during market selloffs as we saw in the 4thquarter of 2008. Reinsurance funds provided valuable diversifications benefits during that period. This brings us to the question: what is reinsurance and how should an investor evaluate managers in this strategy?